Balantidiasis can be diagnosed by laboratory testing of the stool. Immature B. coli parasites (trophozoites) are usually recoverable from the stool. A more complex and more invasive diagnostic method involves scraping the ulcer and examining the tissue for trophozoites.
The antibiotic drug most frequently used to treat Balantidiasis is tetracycline. When tetracycline cannot be given (i.e., allergy), replacement drug therapy may include the drugs iodoquinol or metronidazole. It is not necessary to isolate (quarantine) a person who has Balantidiasis. However, the feces of infected individuals must be disposed of so that they do not come into contact with drinking water or food supplies.